Vitabiotics Menopace Plus

What it is:

A daily dual-tablet supplement containing 26 vitamins, minerals, and plant extracts (sage, soya isoflavones, green tea, flaxseed lignans), marketed for perimenopause and menopause.

What does the trial evidence show?No RCT or systematic review has tested Menopace Plus as a whole product. For individual ingredients:

• Soya isoflavones (100mg/day): A 2024 meta-analysis of 5 RCTs found no significant effect on menopausal symptoms overall [4]. A 2019 overview found some evidence of benefit for hot flushes [5][6].
• Sage extract: A 2023 meta-analysis of 4 studies found a significant reduction in hot flush frequency but not severity, with high variability between studies [7]. The only standalone clinical trial (2011) had no placebo arm, making its findings unreliable [8].
• Flaxseed lignans: No meta-analysis was found on lignans specifically for menopause symptoms. One combination RCT showed improved symptom scores compared to placebo, but it tested soy and flaxseed together and cannot isolate the lignan contribution [10].
• Green Tea extract: No RCT evidence was found specifically linking green tea to menopause symptom relief. The antioxidant claim on the website is a general permitted nutrient claim, not a menopause-specific one.
• Vitamins and minerals: Claims for B6, D, magnesium, zinc, and B1 are based on well-established physiological functions, not menopause-specific trials. Vitamin D at 10µg daily is in line with UK public health guidance [1].

What do guidelines say?

‍NICE guideline NG23 on supplements: it says only that there is "some evidence" isoflavones may relieve vasomotor symptoms, while cautioning that safety varies across preparations. It does not recommend any specific supplement brand or product.

The BMS non-hormonal consensus statement (November 2025) [2] lists isoflavones as a "self-help option" for hot flushes but makes clear that no non-hormonal treatment matches the effectiveness of oestrogen. Neither body names or endorses Menopace Plus.

‍

References

[1] National Institute for Health and Care Excellence. Menopause: Identification and Management (NG23). Published November 2015, updated November 2024. Available at: https://www.nice.org.uk/guidance/ng23. No PMID (clinical guideline).

[2] British Menopause Society. BMS Consensus Statement: Non-hormonal-based treatments for menopausal symptoms. November 2025. Available at: https://thebms.org.uk/wp-content/uploads/2025/11/04-BMS-ConsensusStatement-Non-hormonal-based-treatments-for-menopausal-symptoms-NOV2025-C.pdf. No PMID (clinical guideline).

[3] The Menopause Society (NAMS). The 2023 nonhormone therapy position statement of The North American Menopause Society. Menopause 2023. PMID: 37252752. https://pubmed.ncbi.nlm.nih.gov/37252752/

[4] Gençtürk N, Bilgiç FŞ, Kaban HU et al. The effect of soy isoflavones given to women in the climacteric period on menopausal symptoms and quality of life: Systematic review and meta-analysis of randomized controlled trials. Explore (NY) 2024;20(6):103012. PMID: 38825560. https://doi.org/10.1016/j.explore.2024.05.010

[5] Guo PP, Li P, Zhang XH et al. Complementary and alternative medicine for natural and treatment-induced vasomotor symptoms: An overview of systematic reviews and meta-analyses. Complement Ther Clin Pract 2019;36:181-194. PMID: 31383438. https://doi.org/10.1016/j.ctcp.2019.07.007

[6] Daily JW, Ko BS, Ryuk J et al. Equol Decreases Hot Flashes in Postmenopausal Women: A Systematic Review and Meta-Analysis of Randomized Clinical Trials. J Med Food 2019;22(2):127-139. PMID: 30592686. https://doi.org/10.1089/jmf.2018.4265

[7] Moradi M, Ghavami V, Niazi A et al. The Effect of Salvia Officinalis on Hot Flashes in Postmenopausal Women: A Systematic Review and Meta-Analysis. Int J Community Based Nurs Midwifery 2023;11(3):169-178. PMID: 37489230. https://doi.org/10.30476/IJCBNM.2023.97639.2198

[8] Bommer S, Klein P, Suter A. First time proof of sage's tolerability and efficacy in menopausal women with hot flushes. Adv Ther 2011;28(6):490-500. PMID: 21630133. https://doi.org/10.1007/s12325-011-0027-z

[9] Chang VC, Cotterchio M, Boucher BA et al. Effect of Dietary Flaxseed Intake on Circulating Sex Hormone Levels among Postmenopausal Women: A Randomized Controlled Intervention Trial. Nutr Cancer 2019;71(3):385-398. PMID: 30375890. https://doi.org/10.1080/01635581.2018.1516789

[10] Frigo M, de Barros E, dos Santos PCB et al. Effects of a Cereal Bar with a Combination of Phytoestrogens on the Climacteric Symptoms: A Placebo-Controlled, Randomized Trial. J Am Nutr Assoc 2022;41(3):325-332. PMID: 33734035. https://doi.org/10.1080/07315724.2021.1884143

‍